25I-NBOMe is a novel psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects when administered. 25I-NBOMe can be fatal at heavy doses. It is strongly discouraged to take large amounts of this substance or to insufflate (snort) it.

2C-I-NBOMe, NBOMe-2C-I, Cimbi-5, Smiles, and one of many drugs referred to as N-Bomb

Subjective physical effects include stimulation, perception of bodily lightness, mouth numbing, nausea, temperature regulation suppression, abnormal heart rate, increased blood pressure, muscle cramps and contractions, gustatory hallucinations, pupil dilation, headaches, seizures. Subjective cognitive effects include analysis enhancement, thought acceleration/deceleration, conceptual thinking, anxiety and paranoia, feelings of impending doom, empathy, affection, sociability enhancement, memory suppression, ego death, amnesia, increased libido, time distortion, wakefulness.

The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic 2C-I. It was first synthesized and documented in 2003 by Ralf Heim at the Free University of Berlin. It was further researched by a team at Purdue University led by David Nichols. It has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET).