DMT is a classical psychedelic substance of the tryptamine class. Among psychedelics, it is known for its unique ability to produce short-lived, but intense visionary states and complete hallucinations. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. DMT vapes are becoming more common, where DMT is mixed with a solvent to make the e-liquid, such as propylene glycol, vegetable glycerin, or PEG.

N,N-Dimethyltryptamine, N,N-DMT, Dmitri, The Spirit Molecule, The Glory

When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an “inconceivably high-speed rollercoaster ride.” When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature—this combination is known as pharmahuasca. Unlike most highly prohibited substances, DMT has not been proven to be addictive or physiologically toxic. However, adverse reactions such as severe anxiety, delusions, and psychosis are always possible, even for experienced users, and particularly for those predisposed to mental disorders.

DMT is present in over 65 species of plants, and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents. Its presence is also known to be widespread throughout the plant kingdom. Although various theories have been postulated, its neurobiological function has yet to be determined. DMT was first synthesized in 1931 by the German chemist, Richard Helmuth Fredrick Manske. Its discovery as a natural product is generally credited to Brazilian chemist and microbiologist, Oswaldo Gonçalves de Lima, who, in 1946, isolated an alkaloid he named nigerina (nigerine) from the root bark of jurema preta (Mimosa tenuiflora).