Alpha-PVP is a novel stimulant substance of the cathinone and pyrrolidinophenone classes. α-PVP is chemically related to prolintane and belongs to a group called the substituted cathinones, which includes compounds like MDPV, hexen, and a-PHP. It acts as a norepinephrine-dopamine reuptake inhibitor.

Flakka, Alpha-Pyrrolidinovalerophenone, α-PVP, A-PVP, Flak, O-2387, β-ketone-prolintane, Prolintanone, Gravel

User reports indicate that α-PVP produces powerful, but short-lived stimulant effects comparable to those of methamphetamine and cocaine when insufflated or vaporized. Commonly reported effects include stimulation, disinhibition, increased libido, compulsive redosing, and euphoria. Like other synthetic cathinones, α-PVP is associated with compulsive use and addiction.

α-PVP was patented in the 1960s by Boehringer Ingelheim, although it was never marketed. Reports of its use began to appear in the early 2010s. α-PVP has been subject to much scrutiny by the media as one of the ingredients found in “bath salts” or “legal highs” products. It has been mass produced in China and sold online as a research chemical. It has been linked to numerous hospitalizations and overdose deaths.