5-MeO-DMT is a naturally-occurring psychedelic substance of the tryptamine class. It is structurally related to DMT and 5-HO-DMT (bufotenin) and is reputed to produce the most powerful and intense psychedelic states within the entire class. 5-MeO-DMT produces its effects by binding to serotonin receptors in the brain, although the precise mechanism is not known. 5-MeO-DMT is not a valid substitute for DMT—despite name similarities, they have distinct effects and risk profiles and should be regarded as completely separate entities.

Bufo, The God Molecule, Toad, Jaguar, 5-Methoxy-N,N-dimethyltryptamine

Subjective effects include unity and interconnectedness, time distortion, conceptual thinking, euphoria, and ego loss. 5-MeO-DMT’s psychedelic effects are best compared to DMT in terms of intensity (extreme) and duration (very short). However, it generally lacks a visual geometry component and tends to produce more physical euphoria as well as even stronger transpersonal or mystical-like effects (e.g. ego loss) than DMT.

“It is distributed in a wide variety of plant species, as well as in the venom of a single toad species (Incilius alvarius). Although little is known about its history, it is believed to have been used in South American shamanic practices for centuries. In modern times, both the extracts of the toad venom, as well as synthetic powder form are used, primarily via vaporization.

The synthesis and psychoactive effects were documented by Alexander Shulgin in his 1997 book TiHKAL. Recent studies have demonstrated its capacity to induce mystical experiences, and there is growing interest in exploring its potential therapeutic effects.”