2C-B is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic, mescaline. The mechanism of action is not fully known, although serotonin receptor binding activity is thought to be principally involved.

Nexus, Bromo Mescaline, BDMPEA, Venus, Bees

Subjective effects include open and closed-eye visuals, time distortion, euphoria, and ego loss. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to mescaline, it is described as possessing a less serious or grandiose headspace than tryptamines like LSD or psilocybin mushrooms, placing greater emphasis on the visual and tactile domain.

2C-B was discovered in 1974 by the American chemist, Alexander Shulgin, who was investigating psychedelic phenethylamines derived from mescaline. In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.

Recreational use was observed shortly afterward and it was briefly manufactured and sold commercially under such names as “Erox” and “Nexus” in headshops and adult video stores before being federally scheduled in 1995.